paige.design
Clive Paige
Creative Engineering Specialist
International awards
Shot Show Vegas - Best of Show Sporting Optics
CES Vegas - Winner High End Audio
iF International Design Award - Electric Walker
Over 40 Utility and Design patents filed over 50 years.
New Products - now available for investment/partnership
Micro Lab - Sub miniature i-DIC microscope with micro-fluidics
bioshield LF - Safe Responsible Transparent Surgical Mask
bioshield PAPR-I - Bi-directional Powered Purifying Respirator
Wizz - iF Award Winning Electric Therapeutic Walker
Nature Flex - Elegant Sustainable Aluminium Seating
e-connect - Waterproof Polymer/Carbon/Gold Flat Connector
www.paige.design - updated 3rd October 2025
Micro Lab
Zeta Potential/rouleaux on a smart phone/tablet
The single most cost effective Cardio Vascular
Risk Assessment Device available.
Oxidative stress induces a drop in zeta potential on the surface of the red blood cells and causes cell aggregation in the form of coin stacks referred to as rouleaux. These are seen on the slide as strings. If rouleaux is left untreated, over time increasingly dense rouleaux forms and begins damaging the cardiovascular system - this happens before any noticeable increase in blood pressure occurs.
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Rouleaux is a vital marker for early prediction of hypertension and CVD. If the early
stage of rouleaux strings can be separated by the fluidics then it is very likely that it can be reversed by grounding - a pathway to recovery has been opened up.
TM
Videos taken in 2024 on a Samsung S 25 Ultra
with early Micro Lab prototype.
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The fluidics feature move the red blood cells dynamically against white blood cells that act as stationary microstructures. The 3D dynamic nature and vitality of the cells are observed under near in vivo conditions due to the short time frame of examination. Convolutional neural networks (CNN)'s can be used to model the interaction of cells and compare sample batches of known zeta potential. Micro Lab can then instantly derive an accurate digital readout on new unknown samples.
​The reduction in zeta potential and the formation of rouleaux serves as both a diagnostic marker and a contributing factor. Usually zeta potential, reducing in middle age from a healthy normal level -21mV to -24mV, can reduce to the hypertension level at -10mV to -16mV and below, for a variety of reasons.
TM
Surgical mask compared to bioshield LF
Surgical masks do not filter the majority of the
inhaled or exhaled breath.The exhaled aerosols
are dispersed at head height.
bioshield LF shelters inhaled air and reduces the
height at where exhaled air flow begins to disperse
and also eliminates re-breathing of the exhalate.
Open Source World Registered Designs Utility Patents applied for.
Adjust tension of loops by stretching.
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Adjust gap to around 10mm
Available Product Design Portfolio
Paige Design GmbH are product creators, much like authors create books and artists create paintings. We do not follow what has been done before - we have the freedom to create new product from evolving concept, without being channelled by protocol. We also accept commissions to invent for clients, we continually invent and develop in-house concepts until a product is created with the right genetics, a new generation. Patents and IPR are filed and we then take our offerings to market.
We have a portfolio of new products which have passed proof of concept and have sufficient pre-production development to identify the work required for full production. We also advise on production techniques if required, and can also arrange unusual production techniques like 3D-Free Form bending, non-HAZ water guided laser cutting, plasma surface treatments and specialist powder and conformal coatings. We continually develop new manufacturing techniques such as 3D vacuum forming natural hardwood for our chair seating.
All products created by Paige Design GmbH are unique and are patented or patent pending and usually carry WIPO Design Registration. Design Registration is arguably the most effective IPR protection as the visual elements clearly identify new product and the IPR can be inexpensively defended.
Optional protection during negotiation:
For clients interested in any of our designs or patents we usually use a system where after initial disclosure and discussion, the client company enters into an agreement retaining Paige Design GmbH to provide full access to the product and development details and the IPR. Ownership of the IPR effectively becomes part of the retainer contract and cannot be disclosed or sold to another party while the retainer is in place. This method allows full investigation of the product, market and competitors at low cost without the risk of losing the opportunity of purchasing the IPR during the appraisal period. If for some reason the design does not match project marketing requirements during the retainer contract period, the contract can be cancelled and the IPR reverts to Paige Design GmbH and is then again made available to other clients on the open market.
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The PDF downloads give more background to the products, patents and services provided. Simply sign in for free membership and access to the PDF for each product design.
Preventative health care
- Why awareness of zeta potential is important -
Rouleaux formation can be a light transient phenomenon which is usually reversible with grounding for example. However a significant reduction in zeta potential can lead to rouleaux with a sticky formation resistant to breakup. This is extremely important for individuals to know, so that remedial action can be taken - and progress can be monitored. Due to perhaps an underlying pathology, rouleaux formation can become dense over a short period of time, indicating a significant loss of zeta potential and an increase in blood viscosity, leading to reduced blood flow and various cardiovascular complications.​​ Because tissue perfusion is inversely proportional to blood viscosity, the reduction in zeta potential and the development of rouleaux formation is of great concern and should be addressed as widely as possible. Bi-annual screening of high risk groups to increase awareness and responsibility within the population would be beneficial.
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Implication of reduced zeta potential and dense Rouleaux Formation -
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Underlying pathology that requires further investigation: Elevated triglycerides can lead to changes in plasma proteins, reduced zeta potential and rouleaux formation, chronic kidney disease can cause changes in plasma proteins, including albumin, leading to rouleaux formation.
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Rouleaux formation creates a hyper-coagulable state and may impair oxygen delivery, contributing to tissue ischemia. If the red blood cell aggregation response is indeed systemic, it may have wide reaching multi-systemic effects, including the development or exacerbation of hypertension.
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Morbidity is determined by the patient's underlying health status. Ischemic heart disease, diabetes, prethrombotic states, cancer, peripheral vascular disease, retinopathy, and cerebrovascular insufficiency are among the risk factors that will increase the morbidity associated with the reduction in zeta potential and development of rouleaux.
Detection/Screening
Significant advantage comparison with monitoring zeta potential against monitoring with blood pressure.
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The table lists experimental data which needs to be clinically validated
Other than Micro Lab there is no at-home/point-of-care screening for zeta potential/rouleaux currently available.
Because zeta potential has been a time consuming metric to measure in a path lab - it has not been possible to use as a widespread diagnostic tool. Measurement of zeta potential is usually analysed through access to a research pathology lab - Zeta potential analysers such as Electrophoresis and ELS.​
Given the association between the reduction in zeta potential and rouleaux formation - with hypertension and cardiovascular risk, a smartphone based blood test such as Micro Lab can be extremely beneficial for a wide range of individuals at risk or with pre-existing conditions.
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Facilities that could benefit​
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Pharmacies
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Healthcare clinics
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Doctors surgeries
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Hospitals
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Care homes
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Personal Health Care:
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For those interested in personal health and fitness, the red blood cells shape and dynamics indicate changes in vitality, and an increase in zeta potential can be seen during training, and the impact of dietary regimes/supplements and hydration can be monitored for best effect.
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Those at risk:
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High-risk individuals: Those with a family history of cardiovascular disease, hypertension, diabetes, or kidney disease.
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Adults: Individuals typically over 40 years old, zeta potential decreases with age, and those who do not take regular exercise and have a poor diet.
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Obese or overweight individuals: Those with a body mass index (BMI) of 30 or higher, as obesity is a significant risk factor for cardiovascular disease.
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Individuals at risk of kidney disease or have high triglyceride levels.
Cost saving - CVD Risk assessment - Nation Wide screening for zeta potential
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All adults would benefit from an annual zeta potential pin prick screening, but particularly so with 50–60% of adults over 40 in higher risk groups - where a bi-annual test would be more appropriate.
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There is the potential to save an astonishing $0.5 trillion annually in the USA alone based on projected figures of reduced incidence of CDV by 50% due to screening and suggesting improved lifestyles to maintain or even improve zeta potential in the population through appropriate protocols. Sunshine, exercise, good food and grounding are all important elements - seaside holidays are good for your health!
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The introduction of insurance funded bi-annual zeta potential screening of high risk group of 50M members in the USA would cost around $2 billion based on the cost of infrastructure, with a 250x return on investment. Even with a 1% reduction in disease produces a net saving of $8 billion. This hypothetical example makes a compelling case for zeta potential screening as a cost-effective preventive healthcare strategy.
​Market Potential - Health and Fitness
​The global market for home blood testing devices, which includes finger-prick tests used by health and fitness consumers, was estimated at approximately USD $20 billion in 2025. The market is projected to grow at a compound annual growth rate (CAGR) of 10.3% from 2025 to 2035, reaching an estimated USD 53,3 billion by 2035.
With awareness of the importance of zeta potential testing and the ability for competitive athletes to also increase their zeta potential, Micro Lab at an affordable price could be a market leader.
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Potential Future Developments -
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Artificial intelligence-powered analysis: Leveraging AI to analyse each of the test results and provide personalised recommendations for lifestyle changes and medical interventions.
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Telemedicine integration: Enabling remote monitoring and consultation with healthcare professionals to facilitate timely interventions.
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Point-of-care testing: Integrating the device at all levels allowing for real-time analysis and decision-making.
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Revenue Streams-
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Device sales: Revenue generated from the sale of the Micro Lab
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Subscription services: Offering subscription-based services for data analysis, personalised recommendations, and telemedicine consultations.
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Partnerships and collaborations: Pharmacies, Healthcare providers and insurance companies, to promote the awareness of zeta potential and the benefits of bi-annual screening.
Challenges and Considerations-
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Regulatory hurdles: Navigating regulatory approvals and certifications to ensure the device's safe and effective use.
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Public awareness and adoption: Educating the public about the device's benefits and encouraging adoption.
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Data security and privacy: Ensuring the secure storage and transmission of sensitive health data. The sample slide can be returned to the patient to prevent DNA being harvested without consent.
Reduced Mortality and Morbidity
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The device could lead to a reduction in CVD-related deaths, a saving over time of literally millions of lives.
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By preventing or delaying CVD events, individuals could gain years of life, contributing to a healthier and more productive population.
Public Health Benefits -
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Increased health literacy: Educating the public about cardiovascular risk factors and the benefits of early detection of low zeta potential could improve health awareness and empower individuals to take control of their health.
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Internet examples of high and low zeta potential video blogs could become a thing. Micro fluidics are a fascinating window into human biology.
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Reduced healthcare costs: By reducing the number of hospitalisations, complications, and healthcare services required to manage CVD, the device could lead to significant cost savings and improve accessibility.
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​Reference links to Published articles:
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1.https://www.intechopen.com/chapters/72171
Zeta Potential as a Diagnostic Tool to Determine the Angina Risk
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2.https://newsi8.com/zeta-potential-what-it-is-and-why-it-matters-to-health/
Zeta Potential, What it Is and Why It Matters to Health
3.https://www.liebertpub.com/doi/10.1089/acm.2011.0820
Earthing (Grounding) the Human Body Reduces Blood Viscosity—a Major Factor in Cardiovascular Disease
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Conclusion:
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Blood pressure monitoring has been the mainstay for early diagnosis and for assessing cardiovascular risk and guiding therapeutic interventions. It is clear zeta potential falls earlier and further than blood pressure rises as a result of rouleaux, highlighting it's potential as an early predictive marker. Not until the advent of Micro Lab has this predictive marker been possible to be usefully employed for regular monitoring of blood health. The underlying causes for reduced zeta potential are complex but it has been shown that grounding, lifestyle and dietary changes have a profound effect on improving zeta potential and blood health, and with appropriate management can help mitigate the adverse effects of rouleaux and increased blood viscosity on cardiovascular health.
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Micro Lab
A Pathology Lab in your pocket.
Real-time results - anywhere - anytime
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